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Locomotor Recovery Laboratory: Publications

Gourab, K, Schimt, BD, Hornby, TG. Increased lower limb spasticity but not strength or function following a single-dose serotonin reuptake inhibitor in chronic stroke. Arch Phys Med Rehabil. 2015. In press.

Hornby TG, Holleran CL, Hennessy PW, Leddy AL, Connolly M, Camardo J, Woodward J, Mahtani G, Lovell L, Roth E. Variable Intensive Early Walking Poststroke (VIEWS): A Randomized Controlled Trial.. Neurorehabil Neural Repair.  2015 In press.

Kim HE, Corcos DM, Hornby TG .Increased spinal reflex excitability is associated with enhanced central activation during voluntary lengthening contractions in human spinal cord injury. J Neurophysiol. 2015 May 13. PMID:25972590

Hornby TG, Holleran CL, Leddy AL, Hennessy PW, Leech KA, Connolly M, Moore JL, Straube DD, Lovell L, Roth E. Feasibility of focused stepping practice during in patient rehabilitation post-stroke and potential contributions to mobility outcomes. Neurorehabil Neural Repair.  2015 Feb 26 PMID:25721233

Holleran CL, Rodriguez KS, Echauz T, Leech K, Hornby TG.  Potential contributions of stepping intensity to locomotor outcomes in individuals with chronic stroke. J Neurol Phys Ther. 2015  Apr;39(2):95-102. PMID: 25784587

Lynch M, McCormick ZL, Liem B, Jacobs G, Hwang P, Hornby TG, Rydberg L, Roth E. Energy cost of lower body dressing, pop-over transfers, and manual wheelchair rpropulsion in people with paraplegia due to motor-complete spinal cord injury. Topics in Spinal Cord Injury Rehabil. 2015. 21:2 140-148.

McCormick ZL, Lynch M, Liem B, Jacobs G, Hwang P, Hornby TG, Rydberg L, Roth E. Feasibility for developing cardiovascular exercise recommendations for persons with motor-complete paraplegia based on manual wheelchair propulsion; a protocol and preliminary data.  J Spinal Cord Med. 2015 Jan 13 PMID:25582138

Chu VW, Hornby TG, Schmit BD. Reply to "Perception of lower extremity loading in stroke" Clin Neurophysiol. 2014 Oct 28. pii: S1388-2457(14)00682-8. PMID:2546824

Wei K, Glaser JI, Deng L, Thompson CK, Stevenson IH, Wang Q, Hornby TG, Heckman CJ, Kording KP.  Serotonin affects movement gain control in the spinal cord. J Neurosci. 2014 Sep 17;34(38):12690-700. PMID: 25232107

Elliott JM, Dewald JP, Hornby TG, Walton DM, Parrish TB. Mechanisms Underlying Chronic Whiplash: Contributions from an Incomplete Spinal Cord Injury? Pain Med. 2014 Aug 19. doi: 10.1111/pme.12518. PMID:25139822
Chu VW, Hornby TG, Schmit BD. Perception of lower extremity loads in stroke survivors. Clin Neurophysiol. 2014 Jul 11. pii: S1388-2457(14)00367-8. doi: 10.1016/j.clinph.2014.06.047. [Epub ahead of print] PMID: 25097091

Waddell KJ, Birkenmeier RL, Moore JL, Hornby TG, Lang CE. Feasibility of high-repetition, task-specific training for individuals with upper-extremity paresis. Am J Occup Ther. 2014 Jul-Aug;68(4):444-53. doi: 10.5014/ajot.2014.011619. PMID: 25005508

Kim HE, Thompson CK, Hornby TG. Muscle activation varies with contraction mode in human spinal cord injury.  Muscle Nerve2015 Feb;51(2):235-45.  PMID: 24825184

Hornby TG, Holleran CL. Sleep Matters. J Neurol Phys Ther. 2014 Jul;38(3):170-1.. [Epub ahead of print] PMID: 24806438

Leech KA, Kinnaird CR, Hornby TG. Effects of serotonergic medications on locomotor performance in humans with incomplete spinal cord injury. J Neurotrauma. 2014 Aug 1;31(15):1334-42.

Holleran, CL, Straube DD, Kinnaird CK, Leddy AL, Hornby TG. High intensity stepping training in variable contexts improves locomotor function in individuals post-stroke.. Neurorehabil Neural Repair. 2014 Sep;28(7):643-51. doi: 10.1177/1545968314521001. Epub 2014 Feb 10 PMID:24515925

Straube DD, Kinnaird CK, Holleran, CL, Leddy AL, Hennessy P, Hornby TG. Effects of dynamic stepping training on nonlocomotor tasks in individuals poststroke..Phys Ther. 2014 Jul;94(7):921-33. doi: 10.2522/ptj.20130544. Epub 2014 Mar 13.

O’Donnell LA, Straube DD, Rodriguez KS, Hornby TG. Concurrent Validity of the StepWatch Activity Monitor with Observational Counts of Stepping. 2011. Submitted to Top Stroke Rehabil

Chu VW, Hornby TG, Schmit BD. The effect of antispastic drugs on motor reflexes and voluntary muscle contraction in incomplete spinal cord injury. Arch Phys Med Rehabil. 2014 Apr;95(4):622-32; PMID:24269485

Straube D, Moore J, Leech K, Hornby TG. Item analysis of the berg balance scale in individuals with subacute and chronic stroke. Top Stroke Rehabil. 2013 May-Jun;20(3):241-9. PMID:23841972

Jayaraman A, Thompson CK, Rymer WZ, Hornby TG. Short-term Maximal-Intensity Resistance Training Increases Volitional Function and Strength in Chronic Incomplete Spinal Cord Injury: A Pilot Study. J Neurol Phys Ther. 2013 May 13. [Epub ahead of print]

Courtney CA, O'Hearn MA, Hornby TG. Neuromuscular function in painful knee osteoarthritis. Curr Pain Headache Rep. 2012 Dec;16(6):518-24. doi: 10.1007/s11916-012-0299-2

Thompson CK, Hornby TG. Divergent modulation of clinical measures of volitional and reflexive motor behaviors following serotonergic medication in human incomplete spinal cord injury. J Neurotrauma. 2012 In press. PMID: 22994901

Hornby TG, Kinnaird CR, Holleran CL, Rodriguez KS,  Rafferty MR, Cain JS. Kinematic, electromyographic, and metabolic responses during exoskeletal-, elliptical- or therapist-assisted stepping in incomplete spinal cord injury. Phys Ther.. 2012 92:1278-1291. PMID:22700537

Wu M, Landry J, Schmit BD, Hornby TG, Yen SC.  Robotic resistance treadmill training improves locomotor function in human SCI: a pilot study.  Arch Phys Med Rehabil. 2012. In press.

Hornby TG, Straube DS, Kinnaird CR, Holleran CL, Echauz AJ, Rodriguez KS, Wagner EJ, Narducci EA. Importance of Specificity, Amount and Intensity of Locomotor Training to Improve Ambulatory Function in Patients Post-stroke. Top Stroke Rehabil. 2011 Jul-Aug;18(4):293-307. PMID:21914594

Thompson CK, Lewek MD, Jayaraman A, Hornby TG. Central Excitability Contributes to Supramaximal Volitional Contractions in Human Incomplete Spinal Cord Injury. 2011. J Physiol. Aug PMID: 21610138

Thompson CK, Jayaraman A, Kinnaird CR, Hornby TG. Methods to quantify pharmacologically induced alterations  in motor function in human incomplete SCI. J Vis Exp. 2011 Apr 18;(50). pii: 2148. doi: 10.3791/2148. PMID: 21525848

Frigon A, Thompson CK, Johnson MD, Manuel M, Hornby TG, Heckman CJ. Extra Forces Evoked during Electrical Stimulation of the Muscle or its Nerve Are Generated and Modulated by a Length-Dependent Intrinsic Property of Muscle in Humans and Cats. J  Neurosci. 2011. 13;31(15):5579-88. PMID: 21490198

Theiss RD, Hornby TG, Rymer WZ, Schmit BD. Riluzole decreases flexion withdrawal reflex but not voluntary ankle torque in human chronic spinal cord injury. J Neurophysiol. 105(6):2781-90. PMID: 21430280

Wu M, Hornby TG, Landry JM, Roth H, Schmit BD. A cable-driven locomotor training system for restoration of gait in human SCI. Gait Posture. 2011. 33(2):256-60. PMID: 21232961

Hornby TG, Reinkensmeyer DJ, Chen D. Manually-assisted versus robotic-assisted body weight-supported treadmill training in spinal cord injury: what is the role of each? PMR. 2(3):214-6, 2010. PMID: 20359687

Moore JL, Roth EJ, Killian C, Hornby TG. Locomotor training improves the amount of daily stepping and gait efficiency in individuals post-stroke who have reached a plateau in recovery during conventional rehabilitation. Stroke.41(1):129-35, 2010. PMID: 19910547

Courtney CA, Witte PO, Chmell S, Hornby TG. Heightened flexor withdrawal response in individuals with knee osteoarthritis is modulated by joint compression and joint mobilization. J Pain. 11:179-185, 2010.

Saraf P, Rafferty MR, Kahn JH, Moore JL, Hendron K, Leech K, Hornby TG. Daily stepping in individuals with incomplete spinal cord injury. Phys Ther;90(2):224-35, 2010. PMID: 20022997, PMID: 19910547

Lang CE, MacDonald JR, Reisman DS, Boyd L, Kimberley TJ, Schindler-Ivens SM, Hornby TG, Ross SA, Scheets PL. Observation of amounts of movement practice provided during stroke rehabilitation. Arch Phys Med Rehabil, 2009. 90(10):1692-8.

Courtney CA, Lewek MD, Witte PO, Chmell S, Hornby TG. Increased flexor withdrawal reflex excitability in patients with knee osteoarthritis. J Pain, 2009, In press.

Cotey D, Hornby TG, Gordon KE, Schmit BD. Increases in muscle activity produced by vibration of the thigh muscles during locomotion in chronic human spinal cord injury. Exp Brain Res. 2009 May 29.

Lewek MD, Cruz TH, Moore JL, Roth HR, Dhaher YY, and Hornby TG. Allowing Intralimb Kinematic Variability During Locomotor Training Poststroke Improves Kinematic Consistency: A Subgroup Analysis From a Randomized Clinical Trial. Phys Ther 89: 829-839, 2009. PMID: 19520734

Hornby TG, Lewek MD, Thompson CK, and Heitz R. Repeated Maximal Volitional Effort Contractions in Human Spinal Cord Injury: Initial Torque Increases and Reduced Fatigue. Neurorehabilitation and Neural Repair 23: 928-938, 2009. PMID: 19478056

Kahn JH, Hornby TG.  Rapid and long-term adaptations in gait symmetry following unilateral step training in people with hemiparesis.  Phys Ther. 2009 May;89(5):474-83.

Wu M, Kahn JH, Hornby TG, Schmit BD.  Rebound responses to prolonged flexor reflex stimuli in human spinal cord injury. Exp Brain Res. 2009 Feb;193(2):225-37

Hidler J, Nichols D, Pelliccio M, Brady K, Campbell DD, Kahn JH, Hornby TG. .Multicenter randomized clinical trial evaluating the effectiveness of the Lokomat in subacute stroke. Neurorehabil Neural Repair. 2009 Jan;23(1):5-13.

Hornby TG, Campbell DD, Kahn JH, Demott T, Moore JL, Roth HR. Enhanced gait-related improvements following therapist- vs. robotic-assisted locomotor training in subjects with chronic stroke: a randomized controlled study. Stroke. 2008. 39(6):1786-92.

Bogey RA, Hornby GT. Gait Training Strategies Utilized in Poststroke Rehabilitation: Are We Really Making a Difference? Top Stroke Rehabil. 2007 14(6):1-8.

Lewek MD, Hornby TG, Dhaher YY, Schmit BD. Prolonged Quadriceps Activity Following Imposed Hip Extension: A Neurophysiological Mechanism for Stiff-Knee Gait? J Neurophysiol. 2007. Dec;98(6):3153-62.

Stauffer EK, McDonagh JC, Hornby TG, Reinking RM, Stuart DG. Historical reflections on the after-hyperpolarization-firing rate relation of vertebrate spinal neurons. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2007 Feb;193(2):145-58.

Israel JF, Campbell DD, Kahn JH, Hornby TG. Metabolic costs and muscle activity patterns during robotic- and therapist-assisted treadmill walking in individuals with incomplete spinal cord injury. Phys Ther. 2006, 86:1466-1478.

Lewek MD, Schmit BD, Hornby TG, Dhaher YY. Hip joint position modulates volitional knee extensor muscle activity after stroke. Muscle Nerve. 2006 Dec;34(6):767-774.

Hornby TG, Kahn JK, Wu M, Schmit BD.  Temporal facilitation of spastic stretch reflexes following human spinal cord injury.  J Physiol (Lond) 2006. J Physiol. 2006 Mar 15;571(Pt 3):593-604.

Wu M, Hornby TG, Hilb JA, Schmit BD. Flexor reflex responses triggered by imposed knee extension in chronic human spinal cord injury. Exp Brain Res. 2006;168:566-576.

Hornby TG, Campbell DD, Zemon DH, Kahn JH. Clinical and quantitative evaluation of robotic-assisted treadmill walking to retrain ambulation following spinal cord injury. Top SCI Rehabil. 2005. 11;1-17

Stinear JW, Hornby TG. Stimulation-induced changes in lower limb corticomotor excitability during treadmill walking in humans. J Physiol. 2005. 567:701-711

Deutsch K, Hornby TG, Schmit BD. The intralimb coordination of the flexor reflex response is altered in chronic human spinal cord injury. Neurosci Lett. 2005 Jun;380(3):305-10.

Wu M, Hornby TG, Hilb JA, Schmit BD. Extensor spasms triggered by imposed knee extension in chronic human spinal cord injury. Exp Brain Res. 2005; 162:239-249.

Wirz M, Zemon DH, Rupp R, Scheel A, Colombo G, Dietz V, Hornby TG. Effectiveness of automated locomotor training in patients with a chronic incomplete spinal cord injury: a multicenter trial. Arch Phys Med Rehab. 2005, 86:672-80.

Stauffer EK, Stuart DG, McDonagh JC, Hornby TG, Reinking RM. Afterhyperpolarization-firing rate relation of turtle spinal neurons. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2005 Feb;191(2):135-46

Benz EN, Hornby TG, Bode RK, Scheidt RA, Schmit BD. A physiologically based clinical measure for spasticity in spinal cord injury, Arch Phys Med Rehab 2005, 86:52-59.

Hornby TG, Zemon DH, Campbell D. Use of a robotic device to assist body-weight supported treadmill training in individuals following spinal cord injury. Phys Ther. 2005, 85(1):52-66.

Gorman RB, McDonagh JC, Hornby TG, Reinking RM, Stuart DG. Measurement and nature of firing rate adaptation in turtle spinal neurons. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2005, 191:583-603.

Hornby TG, Tysseling-Mattiace VM, Benz EN, Schmit, B.D. Contribution of muscle afferents to prolonged flexion reflexes following chronic spinal cord injury. J Neurophysiol 2004, 92:3375-3384.

Hornby TG, Heckman CJ, Harvey R, Rymer WZ. Changes in voluntary torque and electromyographic activity following oral baclofen. Muscle Nerve 2004; 30:784-795.

Schmit BD, Hornby TG, Tysseling-Mattiace VM, Benz EN.  Absence of local sign withdrawal in chronic human spinal cord injury, J Neurophysiol, 2003; 90:3232-3241.

Hornby TG, Rymer WZ, Benz EN, Schmit BD. Wind-up of flexion withdrawal in subjects following chronic spinal cord injury: A marker for neuronal plateau potentials? J Neurophysiol 2003, 89:416-426.

Kamper DG, Hornby TG, Rymer WZ. Role of the extrinsic flexor muscles in finger joint flexion. J. Biomech. 2002; 35:1581-1589.

Hornby TG, McDonagh JC, Reinking RM, and Stuart DG.  Effects of excitatory modulation on intrinsic properties of turtle motoneurons. J Neurophysiol. 2002, 88:86-97.

Hornby TG, McDonagh JC, Reinking RM, Stuart DG.. Electrophysiological properties of spinal motoneurons in the adult turtle.  J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2002, 188:397-408.

Hornby TG, McDonagh JC, Reinking RM, Stuart DG. Motoneurons: a preferred firing range across vertebrate species? Muscle Nerve. 2002, 25:632-648.

McDonagh JC, Hornby TG, Reinking RM, Stuart DG. Associations between the morphology and physiology of spinal motoneurons and interneurons in the turtle. J Comp Neurol. 2002, 454:177-191.

Hornby TG, McDonagh JC, Reinking RM, Stuart DG. Associations between the passive, transitional, and active properties of turtle motoneurons. Acta Physiol. Pharm. Bulg.  2001, 26: 15-19.

McDonagh, J.C., Gorman, R.B., Gilliam, E.E., Hornby, T.G., Reinking, R.M. and Stuart, D.G. Electrophysiological and morphological properties on neurons in the ventral horn of the turtle spinal cord.  J. Physiol. (Paris).  1999, 93: 3-16.

McDonagh, J.C., Gorman, R.B., Gilliam, E.E., Hornby, T.G., Reinking, R.M. and Stuart, D.G.  Properties of spinal motoneurons and interneurons in the adult turtle: Provisional classification by cluster analysis.  J. Comp. Neurol. 1998, 400: 544-570.

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